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qsr international
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ANSYS inc
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Simcyp
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Tecplot Inc
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qsr international
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Vital Images Inc
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SPSS Inc
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ANSYS inc
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Image Search Results
Journal: Drug Metabolism and Disposition
Article Title: Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics
doi: 10.1124/dmd.116.071050
Figure Lengend Snippet: The Simcyp liver cirrhosis population PBPK module, which incorporates changes in physiology including cytochrome P450 expression/activity owing to cirrhosis but not changes in transporter expression, was used to predict repaglinide disposition in liver cirrhosis patients (A). Incorporation in the model of changes in OATP1B1 expression owing to cirrhosis improved the prediction of repaglinide disposition in liver cirrhosis patients (B). The observed data are from Hatorp et al. (2000).
Article Snippet: Using the
Techniques: Expressing, Activity Assay